In order to study the effect of internal flow on vortex-induced vibration of flexible riser, the experiment on the vortex-induced vibration of flexible riser transporting fluid in the current was conducted in the physical oceanography laboratory of Ocean University of China.Considering the internal flowing fluid and external marine environment, the dynamic response of the flexible riser was measured.The corresponding numerical simulation was performed using the wake oscillatory model considering the extensibility of the riser system.Both the experiment and the numerical simulation indicated that with the increase of internal flow speed, the response amplitude increases, while the response frequency decreases.