The concentration of 65Zn under artificial conditions in suspended matter, sediment, algae, and excretion as well as its distribution in the organs of fish (Tilapia mossambia), prawn (Penaeus penicillatus), clam (Area granosa), clam (Cyclina sinensis) are studied. The results show a high concentration factor of suspended matter, with a dynamic equilibrium of concentration by lagea arrived after two days. The concentration factor of 65Zn in the intestines of fish, prawn, clam and gills of clam are very high, and their excretive rate is rapid. It shows that the intestines and gills are critical organs of 65Zn concentration. The content of 65Zn in nucleic acid is highest, and is higher in RNA than in DNA, while that in organic acid is lowest.